BDBM50117326 4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide::CHEMBL126699

SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1C)N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N

InChI Key InChIKey=SNGNZNPCCSZZBJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50117326   

TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 29nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 6nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 8.79E+3nMAssay Description:Inhibition of chimeric PDGF receptor with FLT-3 cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 150nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed