BDBM50117319 4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide::CHEMBL125898

SMILES COc1cc2c(ncnc2cc1OCCCN1CCOCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1

InChI Key InChIKey=QRJUFNKCBDLAKR-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50117319   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 40nMAssay Description:Inhibition of chimeric PDGF receptor with FLT-3 cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Fibroblast growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 20nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 60nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Flt3/ITD mutant expressed in hematopoietic cells or AML cell lines; range = 30-100 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of chimeric PDGF receptor with CSF-1R cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 60nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed