BDBM50114791 CHEMBL3609748

SMILES CC(C)CC[C@H](CCC(F)(F)F)N1CC[C@@H](CC(O)=O)C[C@H]1c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=BVLMNAGIBUYCDM-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50114791   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50114791(CHEMBL3609748)Copy SMILESCopy InChI

Affinity DataIC50: 45nMAssay Description:Modulation of gamma-secretase in human SKNBE-2 cells assessed as inhibition of intracellular amyloid beta 42 production after 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/24/2016
Entry Details Article
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