BDBM50112312 2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethyl)-propyl]-benzoyl}-methyl-amino)-pentanedioic acid::CHEMBL56977

SMILES CCC(Cc1coc2nc(N)cc(N)c12)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key InChIKey=IMJCIHFHJWNKIN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50112312   

TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50112312(2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethy...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of Escherichia coli thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50112312(2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50112312(2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethy...)
Affinity DataIC50: 220nMAssay Description:Inhibition of rh dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50112312(2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethy...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of recombinant human thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50112312(2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethy...)
Affinity DataIC50: 440nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed