BDBM50110704 3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol-2-yl-6,7-dihydro-5H-benzo[c]thiophen-4-one::CHEMBL17603

SMILES CC1(C)Cc2c(sc(SCCO)c2C(=O)C1)-c1nccs1

InChI Key InChIKey=QILRYFCEXLFIDS-UHFFFAOYSA-N

Data  12 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50110704   

LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataEC50:  0.700nMAssay Description:Inverse agonist activity at GABAA alpha5beta3gamma2 in Homo sapiens (human) L(tk-) cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to GABAA alpha5beta3gamma2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human GABA A alpha-5-beta-3-gamma-2 receptor, using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  16nMAssay Description:Binding affinity to GABAA alpha2beta3gamma2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-2-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human gamma-amino butyric-acid A receptor alpha-2-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  20nMAssay Description:Binding affinity to GABA-Aalpha1beta3gamma2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-1-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-3-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human gamma-amino butyric-acid A receptor alpha-3-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2, determined using [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  5.46E+3nMAssay Description:Inhibition of human recombinant LRRK2 G2019S mutant using fluorescein- ERM as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed