BDBM50110577 2-(2-((dimethylamino)methyl)phenylthio)-5-iodoaniline::2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-iodo-phenylamine::CHEMBL23034::CHEMBL2314218

SMILES CN(C)Cc1ccccc1Sc1ccc(I)cc1N

InChI Key InChIKey=KPKLDBBNSFWOFA-UHFFFAOYSA-N

Data  18 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50110577   

TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of [125I]IPT uptake at SERT (unknown origin) expressed in LLC-PK1 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity for serotonin transporter expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Inha University

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.0130nMAssay Description:Compound was evaluated for its ability to displace [3H]citalopram binding to the rat cortical Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Inha University

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.0130nMAssay Description:In vitro binding affinity in LLC-PK1 cells by SERT binding assay by using [125I]IDAM as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.0130nMAssay Description:In vitro inhibition of [3H]citalopram binding to human serotonin transporter expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Inha University

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  1.07nMAssay Description:In vitro displacement of [3H]paroxetine from human serotonin transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  683nMAssay Description:Inhibition of [3H]nisoxetine binding to norepinephrine transporter (NET) of rat cortical homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  699nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  699nMAssay Description:In vitro binding affinity in LLC-PK1 cells by Dopamine transporter binding assay by using [125I]IPT as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  699nMAssay Description:In vitro inhibition of [3H]nisoxetine binding to norepinephrine transporter expressed in human kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  840nMAssay Description:Binding affinity for dopamine transporter expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  840nMAssay Description:In vitro inhibition of [3H]WIN-35428 binding to human dopamine transporter expressed in canine kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  840nMAssay Description:In vitro binding affinity in LLC-PK1 cells by Norepinephrine transporter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]-GBR-12,935 binding to dopamine transporter (DAT) of rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi:  1.35E+3nMAssay Description:In vitro displacement of [3H]nisoxetine from human norepinephrine transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(CHEMBL2314218 | 2-(2-Dimethylaminomethyl-phenylsul...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro displacement of [3H]GBR-12935 from human dopamine transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed