BDBM50110484 3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl)-1-(4-(methylsulfonyl)phenyl)-5-phenyl-1H-pyrazole::3-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy)methyl)-1-(4-(methylsulfonyl)phenyl)-5-phenyl-1H-pyrazole::3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazole::3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-1-(4-methanesulfonylphenyl)-5-phenyl-1Hpyrazole::CHEMBL423638

SMILES COC1(CCOCC1)c1cc(F)cc(OCc2cc(-c3ccccc3)n(n2)-c2ccc(cc2)S(C)(=O)=O)c1

InChI Key InChIKey=WSCRVCJAJAXULJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50110484   

TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 1 using monocytes-like cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 2.61E+4nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 5-lipoxygenase activity of compound evaluated as determined by the inhibition of calcium ionophore-induced leukotriene B4 production in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 50nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 300nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 45nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 3nMAssay Description:Inhibition constant against arachidonate 5-lipoxygenase More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of COX2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed