BDBM50109056 5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethoxy}-quinoline::CHEMBL442391

SMILES C(CN1CCC(=CC1)c1c[nH]c2ncccc12)Oc1cccc2ncccc12

InChI Key InChIKey=QFIPWGPAGDXIEC-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50109056   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataIC50: 90nMAssay Description:Antagonism at the 5-hydroxytryptamine 1A receptor in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataIC50: 90nMAssay Description:Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  6.90nMAssay Description:Affinity for RB Serotonin transporter was determined in vitro by incubating compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  72nMAssay Description:In vitro binding affinity towards Human 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  78nMAssay Description:In vitro binding affinity towards Alpha-1 adrenergic receptor was determined by the displacement of [3H]prazosinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109056(5-{2-[4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydr...)
Affinity DataKi:  387nMAssay Description:Affinity for HC Serotonin transporter determined in vitro by incubating compound and [3H]5-HT with human carcinoma (Jar cells), previously treated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed