BDBM50107130 (Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid::2-[5-(4-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-3-methyl-butyric acid::CHEMBL335265

SMILES CC(C)C(N1C(=S)S\C(=C/c2ccc(Br)cc2)C1=O)C(O)=O

InChI Key InChIKey=COHIEJLWRGREHV-UHFFFAOYSA-N

Data  6 KI  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50107130   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Institute of Chemical and Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  4.40E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Institute of Chemical and Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  8.40E+4nMAssay Description:Binding affinity to human Mcl1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  8.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibitory activity against Bcl-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of succinimidyl Oregon Green-labeled Bak-BH3 peptide binding to GST-tagged Bcl-XL (unknown origin) expressed in human Jurkat cells after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  8.70E+3nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  4.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed