BDBM50106737 CHEMBL267865::N-(4-Butyl-2-methyl-phenyl)-N'-hydroxy-formamidine::N-(4-butyl-2-methylphenyl)-N''-hydroxyimidoformamide::N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamide

SMILES CCCCc1ccc(NC=NO)c(C)c1

InChI Key InChIKey=LYNOGBKNFIHKLE-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50106737   

TargetCytochrome P450 3A4(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP3A4 in human kidney microsomes assessed as inhibition of 20-HETE formation using 7-benzyl-oxyquinoline as substrate in presence of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4F11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant CYP4F11 using Luciferin ME EGE as substrate incubated for 30 mins in presence of NADPH by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 4F12(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 155nMAssay Description:Inhibition of human recombinant CYP4F12 using Luciferin ME EGE as substrate incubated for 30 mins in presence of NADPH by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4 using Luciferin-IPA as substrate incubated for 30 mins in presence of NADPH by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 6.32E+3nMAssay Description:Inhibition of human recombinant CYP2C9 using Luciferin CEE as substrate incubated for 30 mins in presence of NADPH by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 using Luciferin-ME EGE as substrate incubated for 30 mins in presence of NADPH by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 4Z1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 601nMAssay Description:Inhibition of CYP4Z1 in human HEK293T cells using Luciferin-BE as substrate incubated for 30 mins in presence of NADPH by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6 in human kidney microsomes assessed as inhibition of 20-HETE formation using 3-[2-(N,N-diethyl-N-methyl-amino)ethyl]-7-methoxy-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2C9 in human kidney microsomes assessed as inhibition of 20-HETE formation using 7-methoxy-4-trifluoromethylcoumarin as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 2.30E+3nMAssay Description:Tested for inhibitory activity against Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 461nMAssay Description:Concentration required to inhibit cytochrome P450 1A2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 272nMAssay Description:Inhibition of cytochrome P450 CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 8.45E+4nMAssay Description:Concentration required to inhibit cytochrome P450 2D6.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 6.54E+4nMAssay Description:Concentration required to inhibit cytochrome P450 3A4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 4.17E+3nMAssay Description:Concentration required to inhibit cytochrome P450 2C9.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 8.39E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human Cytochrome P450 2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed