BDBM50105933 CHEMBL3598051

SMILES CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1

InChI Key InChIKey=JGJWPIOGJPAGQE-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50105933   

TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105933(CHEMBL3598051)
Affinity DataIC50: 4.90nMAssay Description:Binding affinity to GST-tagged RORgamma LBD (unknown origin) assessed as inhibition of interaction with co-activatior peptide TRAP220 preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105933(CHEMBL3598051)
Affinity DataEC50:  10nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) transfected in HEK293T cells after 16 to 20 hrs by GAL4 luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105933(CHEMBL3598051)
Affinity DataEC50:  110nMAssay Description:Inverse agonist activity at RORgamma in C57BL/6 mouse splenocytes assessed as reduction of IL-17 production after 2 days by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105933(CHEMBL3598051)
Affinity DataEC50:  1.90E+3nMAssay Description:Inverse agonist activity at RORalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105933(CHEMBL3598051)
Affinity DataEC50:  1.70E+3nMAssay Description:Inverse agonist activity at RORbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed