BDBM50105051 CHEMBL112624::N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-4-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide

SMILES Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)CO)ncnc1OCCOc1ncc(Br)cn1

InChI Key InChIKey=YAWNVAQKVARTGQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50105051   

TargetEndothelin-1 receptor(Pig)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 0.00620nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 12nMAssay Description:Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 41nMAssay Description:Displacement of 125I-ET1 from pig ETB receptor transfected in grivet COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 41nMAssay Description:Displacement of 125I-ET1 from pig ETB receptor transfected in grivet COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at ET-A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-to...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at ET-B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed