BDBM50103543 CHEMBL3358006

SMILES C[C@@H]1CN(CCN1c1ncc(OCc2ccc(CS(C)(=O)=O)cc2F)cn1)c1nc(no1)C(F)(F)F

InChI Key InChIKey=HXNOCBIFNWVJLT-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50103543   

TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NaV1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CaV1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of IKs channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp based electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) by high throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) by high throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) by high throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) by high throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) by high throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR119 expressed in HEK293S cells assessed as cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103543(CHEMBL3358006)
Affinity DataEC50:  68nMAssay Description:Agonist activity at mouse GPR119 expressed in HEK293S cells assessed as cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed