BDBM50102674 CHEMBL3343051

SMILES O=C(Nc1ccc(NC(=O)c2ccccn2)cc1)c1cccc(c1)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=UKKCHLWQDVEFEM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50102674   

TargetAurora kinase B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 7.51E+3nMAssay Description:Inhibition of human AURKB incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human IRAK4 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human JAK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human JAK2 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human JAK3 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CDK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CDK2 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CDK9 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional protein GlmU(Escherichia coli (strain K12))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 350nMAssay Description:Inhibition of Escherichia coli ATCC 27325 GlmU expressed in Escherichia coli HMS174(DE3) incubated for 15 mins prior to MgCl2 addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50102674(CHEMBL3343051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human IRAK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed