BDBM50102311 3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6,7-dimethyl-pyrazolo[1,5-a]pyrimidine::CHEMBL331921

SMILES Cc1cnc2c(c(nn2c1C)-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1

InChI Key InChIKey=WHGZGEFGZXHTST-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50102311   

TargetProstaglandin G/H synthase 1(Human)
J. Uriach & CíA.

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphomaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
J. Uriach & CíA.

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
J. Uriach & CíA.

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human U-937 cell derived COX1 assessed as reduction in PGE2 level using arachidonic acid as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
J. Uriach & CíA.

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human 143.98.2 cell derived COX2 assessed as reduction in PGE2 level using arachidonic acid as substrate pretreated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
J. Uriach & CíA.

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 12nMAssay Description:Inhibition of COX-2 in human 143982 cells using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
J. Uriach & CíA.

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 12nMAssay Description:Inhibition of COX-2 in human Osteosarcoma cell incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed