BDBM50102282 3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one::CHEMBL112756

SMILES O=c1c(nnc2n(-c3ccccc3)c3ccccc3n12)-c1ccccc1

InChI Key InChIKey=BFVHCJSDSWWYEY-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50102282   

TargetAdenosine receptor A2b(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Bovine)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi:  18nMAssay Description:Binding affinity to bovine adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Bovine)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]CHA from adenosine A1 receptors was determined in bovine cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Bovine)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi:  24.7nMAssay Description:Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes without GTPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Bovine)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi:  25nMAssay Description:Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes with 1 mM GTPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Bovine)
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to bovine adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102282(3,10-Diphenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]t...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]NECA from human A2A adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed