BDBM50098549 (6aR,aR)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile::(6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile::3-Methyl-2-((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzonitrile::CHEMBL28056

SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(-c2c(C)cccc2C#N)c-31

InChI Key InChIKey=APEZAWGOFKUHCA-UHFFFAOYSA-N

Data  23 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50098549   

Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  3.79nMAssay Description:Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]5-HT from rat 5-HT7 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  20.8nMAssay Description:Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  20.8nMAssay Description:Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  20.8nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  20.8nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]5-HT from rat SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]5-HT from rat SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]8-OH-DPAT from rat 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]8-OH-DPAT from rat 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  142nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  142nMAssay Description:Displacement of [3H]-WAY100635 from human 5-HT1A receptor expresssed in stable CHO cell membrane incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  142nMAssay Description:Inhibition of [3H]8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  498nMAssay Description:Inhibition of [3H]raclopride binding to Dopamine receptor D2A in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]raclopride from rat dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]raclopride from rat dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  778nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  778nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  2.47E+3nMAssay Description:Displacement of [3H]raclopride from human dopamine receptor D2A expressed in mouse Ltk cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  2.47E+3nMAssay Description:Displacement of [3H]raclopride from human dopamine receptor D2A expressed in mouse Ltk cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed