BDBM50098389 1-hydroxy-2-(1H-imidazol-5-yl)ethane-1,1-diyldiphosphonic acid::2-(4-imidazole)-1-hydroxy-ethane-1,1-bisphosphonate::CHEMBL301247::[1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]-phosphonic acid::[1-Hydroxy-2-(3H-imidazol-4-yl)-1-phosphono-ethyl]-phosphonic acid

SMILES OC(Cc1cnc[nH]1)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=QJYHEVLLGQDDSN-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50098389   

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)
Affinity DataIC50: 330nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)
Affinity DataIC50: 1.10nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)
Affinity DataIC50: 309nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed