BDBM50097980 CHEMBL169065::methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)acetate::{4-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-piperidin-1-yl}-acetic acid methyl ester

SMILES COC(=O)CN1CCC(CC1)n1cc(-c2cccc(OC)c2)c2c(N)ncnc12

InChI Key InChIKey=IQMVMHITWPJRIL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50097980   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrol...)
Affinity DataIC50: 84nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzyme activity in liquid-phase tyrosine phosphorylation assay at 830 ng/mLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrol...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrol...)
Affinity DataIC50: 2.80E+3nMAssay Description:Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrol...)
Affinity DataIC50: 79.4nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrol...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required for inhibition of v-Abl receptor by tyrosine kinase enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed