BDBM50095514 CHEMBL3590491::US10329294, Example 205

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCC(F)(F)C[C@@H]4N)nc23)c(n1)C(F)(F)F

InChI Key InChIKey=WVWMFKYDECUCDN-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50095514   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095514(CHEMBL3590491 | US10329294, Example 205)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095514(CHEMBL3590491 | US10329294, Example 205)Copy SMILESCopy InChI

Affinity DataIC50: 0.900nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/31/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL