BDBM50095311 CHEMBL3589904

SMILES COc1ccc(Cl)c(c1)-c1ccc(NC(=O)c2ccnn2C)nc1N

InChI Key InChIKey=ZRJGMDIPCQOGNI-UHFFFAOYSA-N

Data  7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50095311   

TargetSodium channel protein type 10 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 190nMAssay Description:Inhibition of human Nav1.8/beta1 expressed in HEK293 cells by manual patch clamp electrophysiologyMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2016
Entry Details Article
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TargetSodium channel protein type 1 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetSodium channel protein type 5 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium channel protein type 9 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium channel protein type 10 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 700nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium channel protein type 10 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50095311(CHEMBL3589904)Copy SMILESCopy InChI

Affinity DataIC50: 190nMAssay Description:Inhibition of Nav1.8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/14/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL