BDBM50093523 CHEMBL3585679::PTP1B spring 6 (6)

SMILES OCc1ccc(-c2ccc(O)cc2)c(C(O)=O)c1C#Cc1ccc(O)cc1

InChI Key InChIKey=VBLCSEMPFRLYCH-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50093523   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Catholic University of Daegu

Curated by ChEMBL
LigandPNGBDBM50093523(CHEMBL3585679 | PTP1B spring 6 (6))
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50093523(CHEMBL3585679 | PTP1B spring 6 (6))
Affinity DataIC50: 8.54E+4nMAssay Description:Inhibition of recombinant human MMP2 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50093523(CHEMBL3585679 | PTP1B spring 6 (6))
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of recombinant human MMP9 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50093523(CHEMBL3585679 | PTP1B spring 6 (6))
Affinity DataIC50: 8.26E+4nMAssay Description:Inhibition of recombinant human MMP3 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Catholic University of Daegu

Curated by ChEMBL
LigandPNGBDBM50093523(CHEMBL3585679 | PTP1B spring 6 (6))
Affinity DataKi:  1.45E+4nM ΔG°:  -6.86kcal/mole IC50: 1.32E+4nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2017
Entry Details

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Catholic University of Daegu

Curated by ChEMBL
LigandPNGBDBM50093523(CHEMBL3585679 | PTP1B spring 6 (6))
Affinity DataKi:  1.45E+4nMAssay Description:Mixed-competitive inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed