BDBM50092249 4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenoxy]-phenol::CHEMBL302481

SMILES CC(C)(C)n1cc(-c2ccc(Oc3ccc(O)cc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=YAUXUMSQGNPGQC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092249   

TargetVascular endothelial growth factor receptor 2(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092249(4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092249(4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092249(4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092249(4-[4-(4-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50: 17nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed