BDBM50092244 5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL69068

SMILES CC(C)(C)n1cc(-c2ccc(Oc3ccc(N)cc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=QJSJCFHSACXKCC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092244   

TargetAngiopoietin-1 receptor(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092244(5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092244(5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092244(5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092244(5-[4-(4-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed