BDBM50092237 6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL66716

SMILES Nc1ncnc2n(C3CCCC3)c(Br)c(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key InChIKey=XPDAMMJGEHXXPI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092237   

TargetVascular endothelial growth factor receptor 2(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092237(6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092237(6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092237(6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092237(6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed