BDBM50092233 7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL307982

SMILES CC(C)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=GTLYPMCHYLJPTD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50092233   

TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 11nMAssay Description:Inhibition of p56 Lck tyrosine kinase at 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 48nMAssay Description:Inhibition of src at 5 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 430nMAssay Description:Inhibition of tie-2 at 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 430nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2 at 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 430nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 430nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 uM ATP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 10nMAssay Description:Inhibition of p56 Lck tyrosine kinase catalytic domain at 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of p56 Lck tyrosine kinase at 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092233(7-Isopropyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 10nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed