BDBM50091830 9-Chloro-8-trifluoromethyl-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one::CHEMBL304013

SMILES FC(F)(F)c1cc2NC(=O)C3CNCCN3c2cc1Cl

InChI Key InChIKey=LSFRIVKFHJGLDR-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50091830   

Target5-hydroxytryptamine receptor 2C(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091830(9-Chloro-8-trifluoromethyl-2,3,4,4a-tetrahydro-1H,...)
Affinity DataEC50:  136nMAssay Description:Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091830(9-Chloro-8-trifluoromethyl-2,3,4,4a-tetrahydro-1H,...)
Affinity DataKi:  9nMAssay Description:Binding affinity using [125I]DOI as radioligand with membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091830(9-Chloro-8-trifluoromethyl-2,3,4,4a-tetrahydro-1H,...)
Affinity DataKi:  84nMAssay Description:Binding affinity using [3H]mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed