BDBM50091641 5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-indazole::CHEMBL114644

SMILES C(C#Cc1ccc2[nH]ncc2c1)N1CCC(Cc2ccccc2)CC1

InChI Key InChIKey=KIDRVLWOPFGWLW-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50091641   

TargetGlutamate receptor ionotropic, NMDA 1(Human)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Human)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataIC50: 380nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Human)
Cocensys

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2C NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University Munster

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at GluN1A/GluN2B receptor (unknown origin) expressed in Xenopus oocytes by voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
University Munster

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L-M(TK-) cell membrane coexpressing GluN1a assessed as inhibition constant measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
University Munster

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]di-o-tolylguanidine from sigma2 receptor in rat liver membrane assessed as inhibition constant measured after 120 mins by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University Munster

Curated by ChEMBL
LigandPNGBDBM50091641(5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1H-ind...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured after 120 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed