BDBM50089863 CHEMBL3577701

SMILES COc1ccc2C(=O)CC(CC(=O)NCCNC(=O)c3ccccc3N3CCC(=O)NC3=O)c2c1

InChI Key InChIKey=KRLQJSZEXYIYPQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50089863   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089863(CHEMBL3577701)
Affinity DataIC50: 288nMAssay Description:Inhibition of hexa-histidine tagged recombinant tankyrase 1 biotinylated catalytic domain (amino acids 1106 to 1325) (unknown origin) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089863(CHEMBL3577701)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of tankyrase 2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089863(CHEMBL3577701)
Affinity DataIC50: 41nMAssay Description:Inhibition of full length PARP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase activity u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089863(CHEMBL3577701)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of tankyrase 2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089863(CHEMBL3577701)
Affinity DataIC50: 290nMAssay Description:Inhibition of hexa-histidine tagged recombinant tankyrase 1 biotinylated catalytic domain (amino acids 1106 to 1325) (unknown origin) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089863(CHEMBL3577701)
Affinity DataIC50: 41nMAssay Description:Inhibition of full length PARP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase activity u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed