BDBM50089814 4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-piperidin-1-yl)-phthalazine-6-carbonitrile; hydrochloride::CHEMBL266960::CHEMBL545712

SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl

InChI Key InChIKey=VDXZLVXFVYDBNH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50089814   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50089814(CHEMBL545712 | CHEMBL266960 | 4-(3-Chloro-4-methox...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50089814(CHEMBL545712 | CHEMBL266960 | 4-(3-Chloro-4-methox...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PDE5 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50089814(CHEMBL545712 | CHEMBL266960 | 4-(3-Chloro-4-methox...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of phosphodiesterase 5 (PDE5) from porcine platelets, range 0.442-0.710More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3',5'-cyclic-AMP phosphodiesterase(Pig)
Eisai

Curated by ChEMBL
LigandPNGBDBM50089814(CHEMBL545712 | CHEMBL266960 | 4-(3-Chloro-4-methox...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 1.01-1.36More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50089814(CHEMBL545712 | CHEMBL266960 | 4-(3-Chloro-4-methox...)
Affinity DataIC50: 984nMAssay Description:Inhibition of phosphodiesterase 2 (PDE2) from porcine platelets, range 0.841-1.15More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphodiesterase(Pig)
Eisai

Curated by ChEMBL
LigandPNGBDBM50089814(CHEMBL545712 | CHEMBL266960 | 4-(3-Chloro-4-methox...)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of phosphodiesterase 3 (PDE3) from porcine platelets, range 11.4-26.9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed