BDBM50089423 (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE::(2R,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide::6-fluoro-2'',5''-dioxo-(2R,4''S)-spiro[3,4-dihydro-2H-chromene-4,4''-(1''H,2''H-imidazole)]-2-carboxamide::6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H-chromene-4,4'-(1'H,2'H-imidazole)]-2-carboxamide::CHEMBL84060

SMILES c1cc2c(cc1F)[C@@]3(C[C@@H](O2)C(=O)N)C(=O)NC(=O)N3

InChI Key InChIKey=WAAPEIZFCHNLKK-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50089423   

TargetAldo-keto reductase family 1 member B1(Rat)
Rational Drug Design Laboratories

Curated by ChEMBL
LigandPNGBDBM50089423(6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H...)
Affinity DataIC50: 570nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50089423(6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H...)
Affinity DataIC50: 570nMAssay Description:Binding affinity for human Aldose reductase 2 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member A1(Pig)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50089423(6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H...)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Rational Drug Design Laboratories

Curated by ChEMBL
LigandPNGBDBM50089423(6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H...)
Affinity DataIC50: 570nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50089423(6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H...)
Affinity DataIC50: 570nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)