BDBM50088394 2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {2-hydroxy-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-amide::CHEMBL309106

SMILES CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)N(C)C)CC1

InChI Key InChIKey=LQTJOPPTSIYEES-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50088394   

TargetAlpha-1A adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards recombinant human 5-hydroxytryptamine 1A receptor was determined using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards recombinant human Dopamine receptor D2L was determined using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  25nMAssay Description:Binding affinity towards recombinant human Dopamine receptor D2S was determined using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  38nMAssay Description:Binding affinity towards histamine H1 receptor was determined in guinea pig brain using [3H]pyrilamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  52nMAssay Description:Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  62nMAssay Description:Binding affinity towards recombinant human Dopamine receptor D3 was determined using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi:  169nMAssay Description:Binding affinity towards rat alpha-2B adrenergic receptor was determined using [3H]yohimbine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088394(2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1...)
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed