BDBM50088392 2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-2-hydroxy-propyl}-amide::CHEMBL419624

SMILES CCOc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)CC1

InChI Key InChIKey=RHILFWFBQHFQIB-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50088392   

TargetAlpha-1A adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088392(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Affinity DataKi:  4.25nMAssay Description:Binding affinity towards cloned human alpha-1A adrenergic receptor was determined using [125]-HEAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088392(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Affinity DataKi:  137nMAssay Description:Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088392(2-(3-Fluoro-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoin...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards cloned human alpha-1B adrenergic receptor was determined using [125]-HEAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed