BDBM50084980 (+)-taxifolin::(-)-Epicatechol::(2R,3R)-(-)-Epicatechin::(2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one::(2R,3R)-dihydroquercetin::(2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone::CHEMBL66::L-Epicatechin

SMILES OC1C(=O)[C@H](Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1

InChI Key InChIKey=BYVWXQRJRYELNP-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50084980   

TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of wild type Amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of wild type His-tagged c-KIT (544 to 976 amino acids) (unknown origin) expressed in insect cells using poly[Glu:Tyr] (4:1) as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against protein kinase C (PKC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article

TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Asp178, Asp177, Hie78, Lys367, Asn75, Il61, Ser362, Gly128 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataKi:  8.50E+3nMAssay Description:Competitive type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataKi:  3.45E+4nMAssay Description:Competitive type inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed