BDBM50083940 4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid (0.2H2O)::CHEMBL184215::CHEMBL278763::Sacchettini_6

SMILES OC(=O)C(=O)CC(=O)c1cccc(Cl)c1

InChI Key InChIKey=OGKORXSMGAWLDU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50083940   

TargetMalate synthase G [C619A](Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
D3R/Abbott

LigandPNGBDBM50083940(CHEMBL278763 | CHEMBL184215 | 4-(3-Chloro-phenyl)-...)
Affinity DataIC50: 170nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetKynurenine 3-monooxygenase(Rat)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50083940(CHEMBL278763 | CHEMBL184215 | 4-(3-Chloro-phenyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFlap endonuclease 1(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50083940(CHEMBL278763 | CHEMBL184215 | 4-(3-Chloro-phenyl)-...)
Affinity DataIC50: 6.96E+3nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA excision repair protein ERCC-5(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50083940(CHEMBL278763 | CHEMBL184215 | 4-(3-Chloro-phenyl)-...)
Affinity DataIC50: 1.31E+4nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed