BDBM50083922 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one::CHEMBL7113

SMILES O=c1c(nnc2[nH]c3ccccc3n12)-c1ccccc1

InChI Key InChIKey=FGCPYWNQYLRWCH-UHFFFAOYSA-N

Data  7 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50083922   

TargetAdenosine receptor A2b(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]CHA from adenosine A1 receptors was determined in bovine cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi:  141nMAssay Description:Intrinsic activity towards Adenosine A1 receptor using [3H]DPCPX from bovine cortical membranes without GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi:  197nMAssay Description:Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes with 1 mM GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi:  728nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of [3H]-CGS- 21680 from adenosine A2a receptor of bovine striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50083922(CHEMBL7113 | 3-Phenyl-10H-benzo[4,5]imidazo[2,1-c]...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]NECA from human A2A adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed