BDBM50082924 6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pteridine-2,4-diamine::CHEMBL342086

SMILES Nc1nc(N)c2nc(CN3c4ccccc4CCc4ccccc34)cnc2n1

InChI Key InChIKey=QQZVNNFURYIWAD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50082924   

TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 910nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
Dartmouth College

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 1.19E+5nMAssay Description:Inhibition of Cryptosporidium hominis DHFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 210nMAssay Description:Inhibition of Pneumocystis carinii DHFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed