BDBM50080252 3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyridin-4-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid::CHEMBL39473

SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccncc3)cc12

InChI Key InChIKey=UXAWVJZJVRJVPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50080252   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080252(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Affinity DataIC50: 48nMAssay Description:Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]L-691831 as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50080252(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Affinity DataIC50: 840nMAssay Description:Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article