BDBM50077578 4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one::CHEMBL59752

SMILES O=C1Cc2c(N1)cccc2OCCNCc1ccccc1

InChI Key InChIKey=CVWQKEFTSSJDLS-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50077578   

TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  0.210nMAssay Description:In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]quinpirole radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of [3H]quinpirole binding to rat striatal membrane Dopamine receptor D2 without GTP and sodiumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of [3H]spiperone binding to human Dopamine receptor D3 in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]spiperone binding to human Dopamine receptor D2 in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]spiperone binding to human Dopamine receptor D4.4 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  11nMAssay Description:In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]spiperone radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  11nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 low affinity without GTP and sodiumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077578(4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one |...)
Affinity DataKi:  306nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT radioligand in rat hippocampal homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed