BDBM50075764 4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine::CHEMBL160490

SMILES Clc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(Cl)cc1

InChI Key InChIKey=XUJSRSRKGLTVPA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075764   

TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50: 220nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50: 810nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50: 160nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50: 190nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50: 4.20E+4nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075764(4-[3,5-Bis-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyrid...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article