BDBM50075578 CHEMBL3415553

SMILES CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c(F)c1

InChI Key InChIKey=WCJKXQIGIZQRIB-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075578   

TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075578(CHEMBL3415553)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075578(CHEMBL3415553)
Affinity DataIC50: 31nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075578(CHEMBL3415553)
Affinity DataKd:  130nMAssay Description:Binding affinity to B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075578(CHEMBL3415553)
Affinity DataKd:  62nMAssay Description:Binding affinity to wild type B-Raf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed