BDBM50069451 (2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol; hydrochloride::CHEMBL555280

SMILES CC(C)(C)[C@H](O)[C@@H](CN)c1ccccc1

InChI Key InChIKey=PBUUNRWQXUBYRS-UHFFFAOYSA-N

Data  3 KI  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50069451   

TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKd:  4.79E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKd:  7.26E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKd:  1.10E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKi:  700nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKi:  4.57E+3nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed