BDBM50069328 CHEMBL3403539::US9688661, 4-(6-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrrole-2-carboxamide (compd 227)

SMILES Cc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1cc(N)ncn1

InChI Key InChIKey=KZJLFVSFVDUMIS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50069328   

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069328(US9688661, 4-(6-aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50069328(US9688661, 4-(6-aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 595nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50069328(US9688661, 4-(6-aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 73nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent