BDBM50065309 3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one::3-[1-(5-Methyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL89697

SMILES Cc1ccc(\C=C2\C(=O)Nc3ccccc23)o1

InChI Key InChIKey=DWJWWZSAYOTJGO-UHFFFAOYSA-N

Data  1 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50065309   

LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataIC50: 7.36E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50065309(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Affinity DataKi:  4.40E+3nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as inhibition constant by ADP hunter plus assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)