BDBM50065284 3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL321781::CHEMBL87402

SMILES Clc1cn[nH]c1C=C1C(=O)Nc2ccccc12

InChI Key InChIKey=GWLUGYITWVGWFU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50065284   

LigandPNGBDBM50065284(CHEMBL321781 | 3-[1-(4-Chloro-1H-pyrazol-3-yl)-met...)
Affinity DataIC50: 7.41E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50065284(CHEMBL321781 | 3-[1-(4-Chloro-1H-pyrazol-3-yl)-met...)
Affinity DataIC50: 7.41E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065284(CHEMBL321781 | 3-[1-(4-Chloro-1H-pyrazol-3-yl)-met...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065284(CHEMBL321781 | 3-[1-(4-Chloro-1H-pyrazol-3-yl)-met...)
Affinity DataIC50: 1.00E+5nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065284(CHEMBL321781 | 3-[1-(4-Chloro-1H-pyrazol-3-yl)-met...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065284(CHEMBL321781 | 3-[1-(4-Chloro-1H-pyrazol-3-yl)-met...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed