BDBM50065058 1-(4-Methoxy-benzyl)-3-(6-methyl-2,4-bis-methylsulfanyl-pyridin-3-yl)-1-[3-(2H-pyrazol-3-yl)-benzyl]-urea::CHEMBL81707

SMILES COc1ccc(CN(Cc2cccc(c2)-c2cc[nH]n2)C(=O)Nc2c(SC)cc(C)nc2SC)cc1

InChI Key InChIKey=RIOWAVRDUCHPKO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50065058   

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065058(1-(4-Methoxy-benzyl)-3-(6-methyl-2,4-bis-methylsul...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory activity towards ACAT by the displacement of [1-14C]oleolyl-CoA from the small intestine of cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065058(1-(4-Methoxy-benzyl)-3-(6-methyl-2,4-bis-methylsul...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed