BDBM50063139 (R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylamino]-3-(1H-indol-3-yl)-propionic acid::CHEMBL155874

SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(NC(=O)c2ccc(Br)cc2)cc1

InChI Key InChIKey=FUXIPODKBLQFAK-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50063139   

TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 2.70nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrilysin(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against endothelin converting enzyme (ECE)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeprilysin(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloprotease-2 MMP2)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed