BDBM50061615 4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahydro-10H-8,15-diaza-cyclohepta[2,1-a;4,5-b']dinaphthalen-7-yl)-benzoic acid::CHEMBL298373

SMILES CN1c2cc3c(cc2N=C(c2ccc(cc2)C(O)=O)c2ccc4ccccc4c12)C(C)(C)CCC3(C)C

InChI Key InChIKey=WJVKVKNDLOYKSA-UHFFFAOYSA-N

Data  6 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50061615   

TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataEC50:  4.00E+3nMAssay Description:Inverse agonist activity at human RoRc-LBD fusion protein with GST expressed in BL-21 (BL3) cells assessed as SRC1 coactivator peptide recruitmentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor gamma(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataKi:  490nMAssay Description:Antagonistic activity towards retinoic acid receptor-gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor beta(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataKi:  500nMAssay Description:Antagonistic activity towards retinoic acid receptor-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor alpha(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataKi:  1.30E+3nMAssay Description:Antagonistic activity towards retinoic acid receptor-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-gamma(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataKi:  1.50E+3nMAssay Description:Antagonistic activity towards retinoid X receptor-gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-beta(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataKi:  1.70E+3nMAssay Description:Antagonistic activity towards retinoid X receptor-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50061615(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)
Affinity DataKi:  3.80E+3nMAssay Description:Antagonistic activity towards retinoid X receptor-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed