BDBM50060993 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID::4'-Fluoro-biphenyl-4-carboxylic acid::CHEMBL106708

SMILES OC(=O)c1ccc(cc1)-c1ccc(F)cc1

InChI Key InChIKey=LXWNTLBMNCXRQN-UHFFFAOYSA-N

Data  2 IC50  7 Kd  2 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50060993   

TargetRegulatory protein E2(Human papillomavirus type 16)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  1.50E+6nMAssay Description:Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  3.00E+5nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetBcl2-associated agonist of cell death(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  4.00E+5nMAssay Description:Binding affinity to BH3 binding groove of BclXLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  4.00E+5nMAssay Description:Binding affinity to Bcl-2 by NMR titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  4.30E+5nMAssay Description:Binding affinity to Bcl-2 by NMR titration assay in presence of 500 uM 1,1-bis(4-chlorophenyl)-3-(dimethylamino)propan-1-olMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataIC50: 3.00E+5nMAssay Description:Binding affinity to Bcl2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to BCL-XL (unknown origin) by 15N HSQC NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation for 6 hrs by Caspase 3/7-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation in presence of 10 % serum for 6 hrs by Caspase 3/7-Glo luminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataIC50: 9.92E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed