BDBM50060898 5,8-Dihydroxy-[1,4]naphthoquinone::5,8-dihydroxy-1,4-dihydronaphthalene-1,4-dione (7a)::5,8-dihydroxy-1,4-naphthoquinone::CHEMBL274056::naphthazalin

SMILES Oc1ccc(O)c2C(=O)C=CC(=O)c12

InChI Key InChIKey=RQNVIKXOOKXAJQ-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50060898   

TargetAmine oxidase [flavin-containing] A(Human)
North-West University

LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 3.19E+3nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAmine oxidase(Human)
North-West University

LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 860nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
Target5-lipoxygenase(Bovine)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 3.00E+3nMAssay Description:5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 2(Human)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 6(Rat)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 1(Mouse)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 9.37E+3nMAssay Description:Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Lahore University of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Lahore University of Management Sciences

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 90nMAssay Description:Inhibition of Aurora A (122 to 403 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in TACC3 phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 490nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed